@inbook{38c9949430774f948993723d41cba62d, title = "Tree-Based Learning of Regulatory Network Topologies and Dynamics with Jump3", abstract = "Inference of gene regulatory networks (GRNs) from time series data is a well-established field in computational systems biology. Most approaches can be broadly divided in two families: model-based and model-free methods. These two families are highly complementary: model-based methods seek to identify a formal mathematical model of the system. They thus have transparent and interpretable semantics but rely on strong assumptions and are rather computationally intensive. On the other hand, model-free methods have typically good scalability. Since they are not based on any parametric model, they are more flexible than model-based methods, but also less interpretable.In this chapter, we describe Jump3, a hybrid approach that bridges the gap between model-free and model-based methods. Jump3 uses a formal stochastic differential equation to model each gene expression but reconstructs the GRN topology with a nonparametric method based on decision trees. We briefly review the theoretical and algorithmic foundations of Jump3, and then proceed to provide a step-by-step tutorial of the associated software usage.", author = "Huynh-Thu, {V{\^a}n Anh} and Guido Sanguinetti", year = "2019", doi = "10.1007/978-1-4939-8882-2_9", language = "English", isbn = "978-1-4939-8881-5", pages = "217--233", editor = "Guido Sanguinetti and Huynh-Thu, {V{\^a}n Anh}", booktitle = "Gene Regulatory Networks: Methods and Protocols", publisher = "Springer New York LLC", }