TY - CHAP
T1 - Tree-Based Learning of Regulatory Network Topologies and Dynamics with Jump3
AU - Huynh-Thu, Vân Anh
AU - Sanguinetti, Guido
PY - 2019
Y1 - 2019
N2 - Inference of gene regulatory networks (GRNs) from time series data is a well-established field in computational systems biology. Most approaches can be broadly divided in two families: model-based and model-free methods. These two families are highly complementary: model-based methods seek to identify a formal mathematical model of the system. They thus have transparent and interpretable semantics but rely on strong assumptions and are rather computationally intensive. On the other hand, model-free methods have typically good scalability. Since they are not based on any parametric model, they are more flexible than model-based methods, but also less interpretable.In this chapter, we describe Jump3, a hybrid approach that bridges the gap between model-free and model-based methods. Jump3 uses a formal stochastic differential equation to model each gene expression but reconstructs the GRN topology with a nonparametric method based on decision trees. We briefly review the theoretical and algorithmic foundations of Jump3, and then proceed to provide a step-by-step tutorial of the associated software usage.
AB - Inference of gene regulatory networks (GRNs) from time series data is a well-established field in computational systems biology. Most approaches can be broadly divided in two families: model-based and model-free methods. These two families are highly complementary: model-based methods seek to identify a formal mathematical model of the system. They thus have transparent and interpretable semantics but rely on strong assumptions and are rather computationally intensive. On the other hand, model-free methods have typically good scalability. Since they are not based on any parametric model, they are more flexible than model-based methods, but also less interpretable.In this chapter, we describe Jump3, a hybrid approach that bridges the gap between model-free and model-based methods. Jump3 uses a formal stochastic differential equation to model each gene expression but reconstructs the GRN topology with a nonparametric method based on decision trees. We briefly review the theoretical and algorithmic foundations of Jump3, and then proceed to provide a step-by-step tutorial of the associated software usage.
U2 - 10.1007/978-1-4939-8882-2_9
DO - 10.1007/978-1-4939-8882-2_9
M3 - Chapter
SN - 978-1-4939-8881-5
SP - 217
EP - 233
BT - Gene Regulatory Networks: Methods and Protocols
A2 - Sanguinetti, Guido
A2 - Huynh-Thu, Vân Anh
PB - Springer New York LLC
CY - New York, NY
ER -