Edinburgh Research Explorer

Unraveling Vascular Inflammation From Immunology to Imaging

Research output: Contribution to journalLiterature review

  • Heather L. Teague
  • Mark A. Ahlman
  • Abass Alavi
  • Denisa D. Wagner
  • Andrew H. Lichtman
  • Matthias Nahrendorf
  • Filip K. Swirski
  • Frank Nestle
  • Joel M. Gelfand
  • Mariana J. Kaplan
  • Steven Grinspoon
  • Paul M. Ridker
  • David E. Newby
  • Ahmed Tawakol
  • Zahi A. Fayad
  • Nehal N. Mehta

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1403-1412
Number of pages10
JournalJournal of the American College of Cardiology
Volume70
Issue number11
Early online date4 Sep 2017
DOIs
Publication statusPublished - 12 Sep 2017

Abstract

Inflammation is a critical factor in early atherosclerosis and its progression to myocardial infarction. The search for valid surrogate markers of arterial vascular inflammation led to the increasing use of positron emission tomography/computed tomography. Indeed, vascular inflammation is associated with future risk for myocardial infarction and can be modulated with short-term therapies, such as statins, that mitigate cardiovascular risk. However, to better understand vascular inflammation and its mechanisms, a panel was recently convened of world experts in immunology, human translational research, and positron emission tomographic vascular imaging. This contemporary review first strives to understand the diverse roles of immune cells implicated in atherogenesis. Next, the authors describe human chronic inflammatory disease models that can help elucidate the pathophysiology of vascular inflammation. Finally, the authors review positron emission tomography-based imaging techniques to characterize the vessel wall in vivo. (J Am Coll Cardiol 2017;70:1403-12) Published by Elsevier on behalf of the American College of Cardiology Foundation.

    Research areas

  • cardiovascular imaging, monocytes, neutrophils, T cells, SYSTEMIC-LUPUS-ERYTHEMATOSUS, POSITRON-EMISSION-TOMOGRAPHY, ACUTE MYOCARDIAL-INFARCTION, RANDOMIZED CLINICAL-TRIAL, ARTERIAL INFLAMMATION, FDG-PET/CT, IN-VIVO, ATHEROSCLEROTIC INFLAMMATION, CHROMATIN DECONDENSATION, IMMUNE-RESPONSES

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