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White matter integrity in individuals at high genetic risk of bipolar disorder

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)350-356
Number of pages7
JournalBiological Psychiatry
Issue number4
Publication statusPublished - 2011


Bipolar disorder is a familial psychiatric disorder associated with reduced white matter integrity, but it is not clear whether such abnormalities are present in young unaffected relatives and, if so, whether they have behavioral correlates. We investigated with whole brain diffusion tensor imaging whether increased genetic risk for bipolar disorder is associated with reductions in white matter integrity and whether these reductions are associated with cyclothymic temperament.

    Research areas

  • Bipolar disorder, cyclothymia, diffusion tensor imaging (DTI), endophenotypes, high risk

ID: 4461008