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Whole brain morphometric analysis of changes associated with pre-term birth

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Original languageEnglish
Title of host publicationMEDICAL IMAGING 2006: IMAGE PROCESSING, PTS 1-3
EditorsJM Reinhardt, JPW Pluim
PublisherSPIE-INT SOC OPTICAL ENGINEERING
Number of pages8
ISBN (Print)0-8194-6423-6
DOIs
Publication statusPublished - 2006
EventMedical Imaging 2006 Conference - San Diego, Canada
Duration: 12 Feb 200614 Feb 2006

Publication series

NameProceedings of SPIE
PublisherSPIE-INT SOC OPTICAL ENGINEERING
Volume6144
ISSN (Print)0277-786X

Conference

ConferenceMedical Imaging 2006 Conference
CountryCanada
CitySan Diego
Period12/02/0614/02/06

Abstract

Pre-term birth is strongly associated with subsequent neuropsychiatric impairment. To identify structural differences in preterm infants we have examined a dataset of magnetic resonance (MR) images containing 88 preterm infants and 19 term born controls. We have analyzed these images by combining image registration, deformation based morphometry (DBM), multivariate statistics, and effect size maps (ESM). The methodology described has been performed directly on the MR intensity images rather than on segmented versions of the images. The results indicate that the approach described makes clear the statistical differences between the control and preterm samples, showing a leave-one-out classification accuracy of 94.74% and 95.45% respectively. In addition, finding the most discriminant direction between the groups and using DBM features and ESM we are able to identify not only what are the changes between preterm and term groups but also how relatively relevant they are in terms of volume expansion and contraction.

    Research areas

  • pattern recognition, statistical methods, magnetic resonance images, deformation-based morphometry., DEFORMATION-BASED MORPHOMETRY, BREAST MR-IMAGES, NONRIGID REGISTRATION, CHILDREN, WEIGHTS, INFANTS

Event

Medical Imaging 2006 Conference

12/02/0614/02/06

San Diego, Canada

Event: Conference

ID: 59298097