Edinburgh Research Explorer

Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution

Research output: Contribution to journalArticlepeer-review

  • D. K. Griffin
  • L. B. Robertson
  • H. G. Tempest
  • A. Vignal
  • V. Fillon
  • R. P. Crooijmans
  • M. A. Groenen
  • S. Deryusheva
  • E. Gaginskaya
  • W. Carre
  • D. Waddington
  • Richard Talbot
  • M. Volker
  • J. S. Masabanda
  • D. W. Burt

Related Edinburgh Organisations

Open Access permissions



  • Download as Adobe PDF

    Rights statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Final published version, 945 KB, PDF document

Original languageEnglish
Pages (from-to)168
Number of pages168
JournalBMC Genomics
Publication statusPublished - Apr 2008


Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the complete sequence of the chicken genome has initiated the development of detailed genomic information in other birds including turkey, an agriculturally important species where mapping has hitherto focused on linkage with limited physical information. No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds.

We present a detailed comparative cytogenetic map between chicken and turkey based on reciprocal chromosome painting and mapping of 338 chicken BACs to turkey metaphases. Two inter-chromosomal changes (both involving centromeres) and three pericentric inversions have been identified between chicken and turkey; and array CGH identified 16 inter-specific CNVs.

This is the first study to combine the modalities of zoo-FISH and array CGH between different avian species. The first insight into the conservation of microchromosomes, the first comparative cytogenetic map of any bird and the first appraisal of CNVs between birds is provided. Results suggest that avian genomes have remained relatively stable during evolution compared to mammalian equivalents.

Download statistics

No data available

ID: 119881