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Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)405-7
Number of pages3
JournalCancer cell
Volume24
Issue number4
DOIs
Publication statusPublished - 14 Oct 2013

Abstract

Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.

    Research areas

  • Animals, Ataxia Telangiectasia Mutated Proteins, BRCA1 Protein, DNA Methylation, Heterochromatin, Humans, Male, Phosphoprotein Phosphatases

ID: 25157501